Treatment of melanoma in-transit metastases with combination intralesional interleukin-2, topical imiquimod, and tretino...

Published in JAAD case reports

A Method for Comprehensive Glycosite-Mapping and Direct Quantitation of Serum Glycoproteins.

Published in Journal of proteome research

A comprehensive glycan map was constructed for the top eight abundant glycoproteins in plasma using both specific and nonspecific enzyme digestions followed by nano liquid chromatography (LC)-chip/quadrupole time-of-flight mass spectrometry (MS) analysis. Glycopeptides were identified using an in-house software tool, GPFinder. A sensitive and repro...

Characteristic Changes in Cell Surface Glycosylation Accompany Intestinal Epithelial Cell (IEC) Differentiation: High Ma...

Published in Molecular & cellular proteomics : MCP

Changes in cell surface glycosylation occur during the development and differentiation of cells and have been widely correlated with the progression of several diseases. Because of their structural diversity and sensitivity to intra- and extracellular conditions, glycans are an indispensable tool for analyzing cellular transformations. Glycans pres...

Dual mTOR Inhibition Is Required to Prevent TGF-β-Mediated Fibrosis: Implications for Scleroderma.

Published in The Journal of investigative dermatology

100% Complete response rate in patients with cutaneous metastatic melanoma treated with intralesional interleukin (IL)-2...

Published in Journal of the American Academy of Dermatology

Patients with cutaneous melanoma metastases have experienced excellent responses to intralesional interleukin (IL)-2. This has led to its recent inclusion into the US National Comprehensive Cancer Network guidelines for management of cutaneous melanoma metastases. Despite this, intralesional IL-2 has not been highlighted in the US literature nor ha...

Patient-centered, direct-access online care for management of atopic dermatitis: a randomized clinical trial.

Published in JAMA dermatology

New models of health care delivery for dermatological care have the potential to increase access and improve patient-centered outcomes. To compare effectiveness of a direct-access, online model for follow-up dermatologic care in pediatric and adult patients with atopic dermatitis with that of in-person office visits. This was a 1-year, randomized c...

Adiposity induces lethal cytokine storm after systemic administration of stimulatory immunotherapy regimens in aged mice...

Published in The Journal of experimental medicine

Aging is a contributing factor in cancer occurrence. We recently demonstrated that systemic immunotherapy (IT) administration in aged, but not young, mice resulted in induction of rapid and lethal cytokine storm. We found that aging was accompanied by increases in visceral fat similar to that seen in young obese (ob/ob or diet-induced obese [DIO]) ...

International consensus criteria for the diagnosis of Raynaud's phenomenon

Published in Journal of Autoimmunity

Vasoconstriction accompanied by changes in skin color is a normal physiologic response to cold. The distinction between this normal physiology and Raynaud's phenomenon (RP) has yet to be well characterized. In anticipation of the 9th International Congress on Autoimmunity, a panel of 12 RP experts from 9 different institutes and four different coun...

Diagnosis and classification of psoriasis

Published in Autoimmunity Reviews

Psoriasis is a chronic inflammatory multi organ disease with well characterized pathology occurring in the skin and often the joints. Although the disease has many characteristic and even pathognomonic features, no established diagnostic criteria exist for cutaneous psoriasis and there is no unified classification for the clinical spectrum of the d...