Eruptive keloids associated with breast cancer: a paraneoplastic phenomenon?
Published in Acta Dermato Venereologica
A public T cell clonotype within a heterogeneous autoreactive repertoire is dominant in driving EAE.
Published in Journal of Clinical Investigation
Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis. Immunization of B10.PL mice with the Ac1-9 peptide, the immunodominant determinant of myelin basic protein (MBP), produced a single episode of EAE followed by recovery and resistance to reinduction of disease. Using the CDR3 length spectratyping technique, we ...
Sentinel lymph node biopsy in patients with thick primary cutaneous melanoma: patterns of use and underuse utilizing a p...
Published in ISRN Dermatology
Background. Sentinel lymph node biopsy (SLNB) for thick cutaneous melanoma is supported by national guidelines. We report on factors associated with the use and underuse of SLNB for thick primary cutaneous melanoma. Methods. The Surveillance, Epidemiology, and End Results database was queried for patients who underwent surgery for thick primary cut...
IL-17A gene transfer induces bone loss and epidermal hyperplasia associated with psoriatic arthritis.
...Published in Annals of the Rheumatic Diseases
Dual mTOR Inhibition Is Required to Prevent TGF-β-Mediated Fibrosis: Implications for Scleroderma.
Published in Journal of Investigative Dermatology
The adaptor protein AP-3 is required for CD1d-mediated antigen presentation of glycosphingolipids and development of Val...
...Published in Journal of Experimental Medicine
Relatively little is known about the pathway leading to the presentation of glycolipids by CD1 molecules. Here we show that the adaptor protein complex 3 (AP-3) is required for the efficient presentation of glycolipid antigens that require internalization and processing. AP-3 interacts with mouse CD1d, and cells from mice deficient for AP-3 have in...
Combination therapy with intralesional triamcinolone and oral dapsone for management of palisaded neutrophilic and granu...
Published in Dermatology online journal
Palisaded neutrophilic and granulomatous dermatitis (PNGD) is a rare granulomatous disease with limited therapeutic options. Herein we present a patient whose skin lesions recurred after surgery and oral steroids, but responded well to a combination of intralesional triamcinolone and oral dapsone.
Blockade of CTLA-4 decreases the generation of multifunctional memory CD4+ T cells in vivo.
Published in The Journal of Immunology
CTLA-4 is known as a central inhibitor of T cell responses. It terminates T cell activation and proliferation and induces resistance against activation induced cell death. However, its impact on memory formation of adaptive immune responses is still unknown. In this study, we demonstrate that although anti-CTLA-4 mAb treatment during primary immuni...
Cyclosporine-induced sebaceous hyperplasia in a hematopoetic stem cell transplant patient: delayed onset of a common adv...
Published in Dermatology online journal
Cyclosporine-induced sebaceous hyperplasia (SH) is a well-documented entity, occurring in up to 30% of renal transplant patients treated with cyclosporine and has also been reported to occur following heart or hematopoetic stem cell transplantation (HCST). Cyclosporine has a stimulatory effect on undifferentiated sebocytes, resulting in the clinica...
Metastatic melanoma - a review of current and future treatment options.
...Published in Acta Dermato Venereologica
Despite advances in treatment and surveillance, melanoma continues to claim approximately 9,000 lives in the US annually (SEER 2013). The National Comprehensive Cancer Network currently recommends ipilumumab, vemurafenib, dabrafenib, and high-dose IL-2 as first line agents for Stage IV melanoma. Little data exists to guide management of cutaneous a...
