Trends in National Institutes of Health Funding of Principal Investigators in Dermatology Research by Academic Degree an...
Published in JAMA Dermatology
NKG2C, HLA-E and their association with psoriasis.
Published in Experimental Dermatology
Natural killer (NK) cell activation is regulated by the integration of signals from inhibitory and activating cell surface receptors. Both NKG2A and NKG2C pair with CD94 to form inhibitory and activating receptors specific for the HLA-E-canonical peptide complex. HLA-E is a non-classical MHC class Ib molecule with limited polymorphism. It preferent...
T cell receptor complementarity determining region 3 length analysis reveals the absence of a characteristic public T ce...
Published in Journal of Experimental Medicine
All adult BALB/c mice immunized with hen egg white lysozyme (HEL) or its dominant determinant, peptide (p)106-116, mount a T cell response using a "public" Vbeta8.2Jbeta1.5 T cell clone. Neonatal exposure to tolerance-inducing doses of antigen can drastically diminish responsiveness in the draining lymph nodes but not in the spleens of animals chal...
T cell clonal expansions detected in patients with primary biliary cirrhosis express CX3CR1.
Published in Journal of Autoimmunity
The intrahepatic biliary destruction of primary biliary cirrhosis (PBC) appears secondary to a multi-lineage response that includes autoantibodies, biliary apotopes, and cellular responses. Although there has been considerable effort in defining the role and specificity of anti-mitochondrial autoantibodies, a major challenge has been the characteri...
A novel in vivo gene transfer technique and in vitro cell based assays for the study of bone loss in musculoskeletal dis...
Published in Journal of Visualized Experiments
Differentiation and activation of osteoclasts play a key role in the development of musculoskeletal diseases as these cells are primarily involved in bone resorption. Osteoclasts can be generated in vitro from monocyte/macrophage precursor cells in the presence of certain cytokines, which promote survival and differentiation. Here, both in vivo and...
Assessing rural-urban disparities in the use of sentinel lymph node biopsy for melanoma.
Published in Journal of Surgical Research
Immunogenicity of self antigens is unrelated to MHC-binding affinity: T-cell determinant structure of Golli-MBP in the B...
Published in Journal of Autoimmunity
The classical myelin basic protein (MBP) exons belong to a much larger unit, termed the Golli-MBP gene. Here we have examined the T-cell determinant structure of the Golli protein region in the BALB/c mouse. Golli p10-24, which was shown to have the strongest affinity for I-A(d), could not induce T-cell activation. Paradoxically, the poorer bin...
Urogynecologic complications in Stevens-Johnson syndrome and toxic epidermal necrolysis: Presentation of a case and reco...
Published in JAAD Case Reports
Acrodermatitis enteropathica and an overview of zinc metabolism.
Published in Journal of the American Academy of Dermatology
Acrodermatitis enteropathica is a rare autosomal recessive disorder of zinc deficiency. The genetic defect has been mapped to 8q24 and the defective gene identified as SLC39A4, which encodes the zinc transporter Zip4. The diagnosis is made by way of clinical presentation together with histopathology and laboratory tests. Here we provide an overview...
Protein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalomyelitis.
...Published in Nature Biotechnology
The diversity of autoimmune responses poses a formidable challenge to the development of antigen-specific tolerizing therapy. We developed myelin proteome microarrays to profile the evolution of autoantibody responses in experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis (MS). Increased diversity of autoantibody respo...
