Maverakis Lab - UC Davis
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News 74 Publications 1 Members

Detailed protocol for administration of intralesional IL-2 for the treatment of Stage IIIc and IV M1a metastatic melanom...

Patel, F Wilken, R Burrall, B Martinez, S Wells, V King, B Emanual Maverakis

Published in Dermatology online journal

Melanoma claims approximately 9,000 lives in the United States annually. Patients who present with satellite, in-transit, or distant cutaneous metastases have limited treatment options and the prognosis for patients with metastatic disease remains poor. Surgical excision remains the most common treatment modality for cutaneous metastases, but may n...

Multimodal therapy of idiopathic pyoderma gangrenosum.

Sharon, V Burrall, B Patel, F He, Y Konia, T Villalobos, Ib Emanual Maverakis

Published in Dermatology online journal

A 13-year old girl was admitted to the University of California Davis Medical Center for evaluation and treatment of cutaneous bullae and ulcerations over her lower extremities that were refractory to antibiotic therapy and incision and drainage. Her disease continued to worsen with the appearance of multiple new bullae and the progression of old o...

Acrodermatitis enteropathica.

Emanual Maverakis Lynch, Pj Fazel, N

Published in Dermatology online journal

A 13-year-old girl presented with a history of red scaly plaques involving the chest, arms and legs beginning in infancy. Punch biopsy revealed psoriasiform hyperplasia and pallor of the epidermis. The patient s serum zinc level was 36 mug/dl [nl. 66-144 mug/dl]. A diagnosis of acrodermatitis enteropathica was established and the patient responded ...

Mechanical disruption of tumors by iron particles and magnetic field application results in increased anti-tumor immune ... PDF available through Get Fulltext Research

Bouchlaka, Mn Sckisel, Gd Wilkins, D Emanual Maverakis Monjazeb, Am Fung, M Welniak, L Redelman, D Fuchs, A Evrensel, Ca ...

Published in PLoS ONE

The primary tumor represents a potential source of antigens for priming immune responses for disseminated disease. Current means of debulking tumors involves the use of cytoreductive conditioning that impairs immune cells or removal by surgery. We hypothesized that activation of the immune system could occur through the localized release of tumor a...

Mycobacterium chelonae infection presenting as recurrent cutaneous and subcutaneous nodules—a presentation previously di...

Emanual Maverakis He, Y Patel, Fb Fitzmaurice, S Fung, Ma

Published in Dermatology online journal

Although the dermatologic community rarely uses "Weber-Christian Disease" as a diagnosis, it still appears in the internal medicine literature. Herein we present a patient with recurrent cutaneous and subcutaneous nodules who was initially treated with aggressive immunosupression for a presumptive diagnosis of Weber-Christian Disease. After more th...

Autoreactive T cells can be protected from tolerance induction through competition by flanking determinants for access t...

Emanual Maverakis Beech, J Stevens, Db Ametani, A Brossay, L Van Den Elzen, P Mendoza, R Thai, Q Macias, Lh Ethell, D ...

Published in Proceedings of the National Academy of Sciences

It is not clear why the N-terminal autoantigenic determinant of myelin basic protein (MBP), Ac1-9, is dominant in the B1O.PL (H-2(u)) mouse, given its weak I-A(u)-MHC binding affinity. Similarly, how do high-affinity T cells specific for this determinant avoid negative selection? Because the MBP:1-9 sequence is embryonically expressed uniquely in t...

Molecular characterization of the T cell repertoire using immunoscope analysis and its possible implementation in clinic...

Ria, F Van Den Elzen, P Madakamutil, Lt Miller, Je Emanual Maverakis Sercarz, Ee

Published in Current Molecular Medicine

T lymphocytes play a central role in the pathogenesis of a large number of human conditions including autoimmunity and graft rejection. Although T cells are key players in mounting immune responses, the assessment of T cell repertoires has yet to find an important role in clinical decision making. In this review, we discuss the "immunoscope" techni...

Mhc-guided processing: binding of large antigen fragments.

Sercarz, Ee Emanual Maverakis

Published in Nat Rev Immunol

Ever since the emergence of models for the processing and presentation of antigenic determinants by MHC class II molecules, the main view has been that proteins are unfolded, enzymatically cleaved into peptide lengths of about 12-25 amino acids and then loaded onto MHC class II molecules. There is, however, an alternative model stating that partial...

Residual public repertoires to self.

Wilson, Ss Van Den Elzen, P Emanual Maverakis Beech, Jt Braciak, Ta Kumar, V Sercarz, Ee

Published in Journal of Neuroimmunology

The consensus view about the constitution of the T cell receptor repertoire has shifted greatly even during this decade. Although the discovery of autoimmunity in the fifties had clearly shown that a repertoire must exist directed against self antigens, the extent of this repertoire was not fully appreciated. In our work we have tried to elucidate ...

Acute guttate psoriasis in a 15-year-old girl with Epstein-Barr virus infection.

Loh, E Fung, Ma Emanual Maverakis

Published in Archives of Dermatology

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