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Limited clonality in autoimmunity: drivers and regulators.

Van Den Elzen, P Menezes, Js Ametani, A Emanual Maverakis Madakamutil, L Tang, Xl Kumar, V Sercarz, Ee

Published in Autoimmunity Reviews

The available T cell repertoire directed against self is appreciable owing to the escape of many clones from negative selection, largely because many determinants on self proteins are cryptic and not presented adequately. In addition, the degeneracy of T cell receptor specificity permits each lymphocyte a broad recognitive potential. Within the ava...

Diagnosis and classification of psoriasis

Raychaudhuri, Smriti K. Maverakis, Emanual Raychaudhuri, Siba P.

Published in Autoimmunity Reviews

Psoriasis is a chronic inflammatory multi organ disease with well characterized pathology occurring in the skin and often the joints. Although the disease has many characteristic and even pathognomonic features, no established diagnostic criteria exist for cutaneous psoriasis and there is no unified classification for the clinical spectrum of the d...

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