Maverakis Lab - UC Davis
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International consensus criteria for the diagnosis of Raynaud's phenomenon

Maverakis, Emanual Patel, Forum Kronenberg, Daniel G. Chung, Lorinda Fiorentino, David Allanore, Yannick Guiducci, Serena Hesselstrand, Roger Hummers, Laura K. Duong, Chris ...

Published in Journal of Autoimmunity

Vasoconstriction accompanied by changes in skin color is a normal physiologic response to cold. The distinction between this normal physiology and Raynaud's phenomenon (RP) has yet to be well characterized. In anticipation of the 9th International Congress on Autoimmunity, a panel of 12 RP experts from 9 different institutes and four different coun...

Self-reactive T cells and degeneracy of T cell recognition: evolving concepts-from sequence homology to shape mimicry an...

Emanual Maverakis Van Den Elzen, P Sercarz, Ee

Published in Journal of Autoimmunity

Light, including ultraviolet.

E, Maverakis Y, Miyamura Mp, Bowen G, Correa Y, Ono H, Goodarzi

Published in Journal of Autoimmunity

Ultraviolet (UV) light is intricately linked to the functional status of the cutaneous immune system. In susceptible individuals, UV radiation can ignite pathogenic inflammatory pathways leading to allergy or autoimmunity. In others, this same UV radiation can be used as a phototherapy to suppress pathogenic cutaneous immune responses. These vastly...

Presentation of a determinant by MHC class II can be prevented through competitive capture by a flanking determinant on ...

E, Maverakis Jt, Beech S, Schneider Ee, Sercarz

Published in Journal of Autoimmunity

Competitive capture is a process by which different determinants of an unfolding antigen compete for binding to the same MHC class II molecule. The "winning" determinant is then dominantly displayed. For self antigens, T cells with specificity for dominantly displayed determinants will be subject to strong tolerance induction. With this in mind we ...

Glycans in the immune system and The Altered Glycan Theory of Autoimmunity: a critical review. PDF available through Get Fulltext Research

Emanual Maverakis Kim, K Shimoda, M Gershwin, Me Patel, F Wilken, R Raychaudhuri, S Ruhaak, Lr Lebrilla, Cb

Published in Journal of Autoimmunity

Herein we will review the role of glycans in the immune system. Specific topics covered include: the glycosylation sites of IgE, IgM, IgD, IgE, IgA, and IgG; how glycans can encode "self" identity by functioning as either danger associated molecular patterns (DAMPs) or self-associated molecular patterns (SAMPs); the role of glycans as markers of pr...

T cell clonal expansions detected in patients with primary biliary cirrhosis express CX3CR1.

Zhang, W Ono, Y Miyamura, Y Bowlus, Cl Gershwin, Me Emanual Maverakis

Published in Journal of Autoimmunity

The intrahepatic biliary destruction of primary biliary cirrhosis (PBC) appears secondary to a multi-lineage response that includes autoantibodies, biliary apotopes, and cellular responses. Although there has been considerable effort in defining the role and specificity of anti-mitochondrial autoantibodies, a major challenge has been the characteri...

Immunogenicity of self antigens is unrelated to MHC-binding affinity: T-cell determinant structure of Golli-MBP in the B...

Emanual Maverakis Mendoza, R Southwood, S Raja-Gabaglia, C Abromson-Leeman, S Campagnoni, At Sette, A Sercarz, Ee

Published in Journal of Autoimmunity

The classical myelin basic protein (MBP) exons belong to a much larger unit, termed the Golli-MBP gene. Here we have examined the T-cell determinant structure of the Golli protein region in the BALB/c mouse. Golli p10-24, which was shown to have the strongest affinity for I-A(d), could not induce T-cell activation. Paradoxically, the poorer bin...

A T cell-binding fragment of fibrinogen can prevent autoimmunity.

Takada, Yoshikazu Ono, Yoko Saegusa, Jun Sagusa, Jun Mitsiades, Constantine Mitsiades, Nicholas Tsai, Jean He, Yong Maningding, Ernest Coleman, Annie ...

Published in Journal of autoimmunity

The C-terminal domain of the fibrinogen gamma chain (gammaC) has been shown to bind to the integrins alphaIIbbeta3, alphaMbeta2 and alphaVbeta3. It has also been reported that a peptide derived from the alphaMbeta2-binding site of gammaC can suppress an animal model of multiple sclerosis, experimental autoimmune encephalomyelitis (EAE). Here we hav...

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