Maverakis, Emanual Menezes, Juscilene S. Ametani, Akio Han, Mei Stevens, David B. He, Yong Wang, Yan Ono, Yoko Miyamura, Yoshinori Lam, Kit S.
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Published in
Proceedings of the National Academy of Sciences of the United States of America
To determine the role that competition plays in a molecular mimic’s capacity to induce autoimmunity, we studied the ability of naïve encephalitogenic T cells to expand in response to agonist altered peptide ligands (APLs), some capable of stimulating both self-directed and exclusively APL-specific T cells. Our results show that although the APLs ca...
Emanual Maverakis Beech, J Stevens, Db Ametani, A Brossay, L Van Den Elzen, P Mendoza, R Thai, Q Macias, Lh Ethell, D
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Published in
Proceedings of the National Academy of Sciences
It is not clear why the N-terminal autoantigenic determinant of myelin basic protein (MBP), Ac1-9, is dominant in the B1O.PL (H-2(u)) mouse, given its weak I-A(u)-MHC binding affinity. Similarly, how do high-affinity T cells specific for this determinant avoid negative selection? Because the MBP:1-9 sequence is embryonically expressed uniquely in t...
